A class act: HDAC1-Malat1 regulates MDSC apoptosis and cell cycling to decrease suppression of T cells. Aaron G. Baugh, Yingtong Liu, Edgar Gonzalez, Batul Al-Zubeidy, Mukund Iyer, Alexander H. Lee, Nana Gyabaah-Kessie, Matthew B. Jacobo, Cheol Park, Jesse Kreger, Lori Khatchaturian, Sabrina K. Zhong, Kaliya Acevedo, Saul J. Priceman, Josh Neman, Adam L. MacLean, Evanthia T. Roussos Torres. Submitted 2026. https://doi.org/10.64898/2026.03.23.713743
Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer. Jesse Kreger, Edgar Gonzalez, Xiaojun Wu, Evanthia T. Roussos Torres, and Adam L. MacLean. Submitted 2025. https://doi.org/10.1101/2025.08.11.669777
Immune Circuit Rewiring by HDAC Inhibition Enables Response to Dual Checkpoint Blockade in Metastatic Breast Cancer. Edgar Gonzalez*, Jesse Kreger*, Yingtong Liu, Xiaojun Wu, Arianna Barbetta, Aaron G. Baugh, Batul Al-Zubeidy, Julie Jang, Sarah M. Shin, Zhehao Zhang, Amanda Poissonnier, Matthew Jacobo, Vered Stearns, Roisin M. Connolly, Won Ho, Juliet Emamaullee, Adam L. MacLean, and Evanthia T. Roussos Torres. Published in Cancer Research 2026. https://doi.org/10.1158/0008-5472.CAN-26-1086
Sequencing analysis reveals evidence of immune activation in advanced HER2 negative breast cancer responders treated with entinostat + nivolumab + ipilimumab. Ludmila Danilova, Joseph A. Tandurella, Edgar Gonzalez, Alexander Hopkins, Jesse Kreger, Judy Murray, Melinda Downs, Aaron Baugh, Batul Al-Zubeidy, Luciane T. Kagohara, Adam L. MacLean, Vered Stearns, Roisin M. Connolly, Elana J. Fertig, and Evanthia T. Roussos Torres. Published in Communications Medicine 2026. https://doi.org/10.1038/s43856-026-01908-9
Intratumoral CXCL12 Gradients Contextualize Tumor Cell Invasion, Migration and Immune Suppression in Breast Cancer. Dimitra P. Anastasiadou, Nicole Couturier, Sakshi Goel, Dimitrios G. Argyris, Stepan Vodopyanov, Luis Rivera-Sanchez, Edgar Gonzalez, Jesse Kreger, et al. Submitted 2024. https://doi.org/10.1101/2024.10.15.618571
Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life. Jesse Kreger, Jazlyn A. Mooney, Darryl Shibata, and Adam L. MacLean. Published in Nature Communications 2024. https://doi.org/10.1038/s41467-024-54711-2
A new Neu - a syngeneic model of spontaneously metastatic HER2-positive breast cancer. Aaron G. Baugh, Edgar Gonzalez, Valerie H. Narumi, Jesse Kreger, Yingtong Liu, Christine Rafie, Sofi Castanon, Julie Jang, Luciane T. Kagohara, Dimitra P. Anastasiadou, James Leatherman, Todd D. Armstrong, Isaac Chan, George S. Karagiannis, Elizabeth M. Jaffee, Adam L. MacLean, and Evanthia T. Roussos Torres. Published in Clinical & Experimental Metastasis 2024. https://doi.org/10.1007/s10585-024-10289-z
Gastrulation-stage gene expression in Nipbl+/- mouse embryos foreshadows the development of syndromic birth defects. Stephenson Chea, Jesse Kreger, Martha E. Lopez-Burks, Adam L. Maclean, Arthur D. Lander, and Anne Calof. Published in Science Advances 2024. https://doi.org/10.1126/sciadv.adl4239
Myeloid-derived suppressor cell dynamics control outcomes in the metastatic niche. Jesse Kreger, Evanthia T. Roussos Torres, and Adam L. MacLean. Published in Cancer Immunology Research 2023. https://doi.org/10.1158/2326-6066.CIR-22-0617
The role of migration in mutant dynamics in fragmented populations. Jesse Kreger, Donovan Brown, Natalia L. Komarova, Dominik Wodarz, and Justin Pritchard. Published in Journal of Evolutionary Biology 2022. http://doi.org/10.1111/jeb.14131
A hybrid stochastic-deterministic approach to explore multiple infection and evolution in HIV. Jesse Kreger, Natalia L. Komarova, and Dominik Wodarz. Published in PLOS Computational Biology 2021. https://doi.org/10.1371/journal.pcbi.1009713
Quantifying the dynamics of viral recombination during free virus and cell-to-cell transmission in HIV-1 infection. Jesse Kreger, Josephine Garcia, Hongtao Zhang, Natalia L. Komarova, Dominik Wodarz, and David N. Levy. Published in Virus Evolution 2021. https://doi.org/10.1093/ve/veab026
Effect of synaptic cell-to-cell transmission and recombination on the evolution of double mutants in HIV. Jesse Kreger, Natalia L. Komarova, and Dominik Wodarz. Published in Journal of the Royal Society Interface 2020. https://doi.org/10.1098/rsif.2019.0832
*co-first authors