• ability to build and understand highly technical algorithms/math models
• ability to build and understand code to analyze complicated data (in multiple languages)
• ability to understand complex biological systems and identify their most important components
• ability to learn new things quickly, ability to adapt and pivot, and ability to communicate ideas/mathematics in simple terms

• cell dynamics and fate using mathematical modeling and high-dimensional sequencing data
• disease dynamics (such as cancer and viruses)
• evolution in complex populations

Publications and projects

• Characterization of immune infiltration of a metastatic tumor microenvironment of murine breast cancer treated with entinostat and dual checkpoint blockade. Jesse Kreger, Yingtong Liu, Edgar Gonzalez, Aaron G. Baugh, Evanthia T. Roussos Torres, Adam L. MacLean, et al. In preparation. 2024.

• Intratumoral CXCL12 Gradients Contextualize Tumor Cell Invasion, Migration and Immune Suppression in Breast Cancer. Dimitra P. Anastasiadou, Nicole Couturier, Sakshi Goel, Dimitrios G. Argyris, Stepan Vodopyanov, Luis Rivera-Sanchez, Edgar Gonzalez, Jesse Kreger, et al. Submitted. 2024. https://doi.org/10.1101/2024.10.15.618571

• Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life. Jesse Kreger, Jazlyn A. Mooney, Darryl Shibata, and Adam L. MacLean. Published in Nature Communications. 2024. https://doi.org/10.1038/s41467-024-54711-2

• A new Neu - a syngeneic model of spontaneously metastatic HER2-positive breast cancer. Aaron G. Baugh, Edgar Gonzalez, Valerie H. Narumi, Jesse Kreger, Yingtong Liu, Christine Rafie, Sofi Castanon, Julie Jang, Luciane T. Kagohara, Dimitra P. Anastasiadou, James Leatherman, Todd D. Armstrong, Isaac Chan, George S. Karagiannis, Elizabeth M. Jaffee, Adam MacLean, and Evanthia T. Roussos Torres. Published in Clinical & Experimental Metastasis 2024. https://doi.org/10.1007/s10585-024-10289-z

• Gastrulation-stage gene expression in Nipbl+/- mouse embryos foreshadows the development of syndromic birth defects. Stephenson Chea, Jesse Kreger, Martha E. Lopez-Burks, Adam L. Maclean, Arthur D. Lander, and Anne Calof. Published in Science Advances 2024. https://doi.org/10.1126/sciadv.adl4239

• Myeloid-derived suppressor cell dynamics control outcomes in the metastatic niche. Jesse Kreger, Evanthia T. Roussos Torres, and Adam L. MacLean. Published in Cancer Immunology Research 2023. https://doi.org/10.1158/2326-6066.CIR-22-0617 

• The role of migration in mutant dynamics in fragmented populations. Jesse Kreger, Donovan Brown, Natalia L. Komarova, Dominik Wodarz, and Justin Pritchard. Published in Journal of Evolutionary Biology December 2022. http://doi.org/10.1111/jeb.14131

• A hybrid stochastic-deterministic approach to explore multiple infection and evolution in HIV. Jesse Kreger, Natalia L. Komarova, and Dominik Wodarz. Published in PLOS Computational Biology December 2021. https://doi.org/10.1371/journal.pcbi.1009713

• Quantifying the dynamics of viral recombination during free virus and cell-to-cell transmission in HIV-1 infection. Jesse Kreger, Josephine Garcia, Hongtao Zhang, Natalia L. Komarova, Dominik Wodarz, and David N. Levy. Published in Virus Evolution March 2021. https://doi.org/10.1093/ve/veab026

• Effect of synaptic cell-to-cell transmission and recombination on the evolution of double mutants in HIV. Jesse Kreger, Natalia L. Komarova, and Dominik Wodarz. Published in Journal of the Royal Society Interface March 2020. https://doi.org/10.1098/rsif.2019.0832

Blog posts

• Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life - Behind the Paper. Jesse Kreger and Adam L. MacLean. Published in Mathematical Oncology Blog April 2024. https://mathematical-oncology.org/blog/developmental-hematopoietic-stem-cell-fate

• Myeloid-derived suppressor cell dynamics control outcomes in the metastatic niche - Behind the Paper. Jesse Kreger. Published in Mathematical Oncology Blog June 2022. https://mathematical-oncology.org/blog/MDSC-dynamics-metastatic-niche

undergraduate Research Supervised

past projects