Research

For a list of conference talks, symposia organized, awards (and more), see my CV
I am broadly interested in problems that lie at the interface of mathematics and biology. I enjoy collaborating with other scientists and also have numerous experiences leading undergraduate research projects.
Some current research directions include:
  • in vivo virus dynamics (specifically HIV)
  • evolution of mutants in fragmented populations
  • cell dynamics, signaling, and fate control using mathematical modeling and single-cell sequencing data (specifically during tumorigenesis and metastasis)

projects and publications

Virus dynamics

  • Effect of synaptic cell-to-cell transmission and recombination on the evolution of double mutants in HIV. Jesse Kreger, Natalia L. Komarova, and Dominik Wodarz. Published in Journal of the Royal Society Interface March 2020. https://doi.org/10.1098/rsif.2019.0832

  • Quantifying the dynamics of viral recombination during free virus and cell-to-cell transmission in HIV-1 infection. Jesse Kreger, Josephine Garcia, Hongtao Zhang, Natalia L. Komarova, Dominik Wodarz, and David N. Levy. Published in Virus Evolution March 2021. https://doi.org/10.1093/ve/veab026

  • A hybrid stochastic-deterministic approach to explore multiple infection and evolution in HIV. Jesse Kreger, Natalia L. Komarova, and Dominik Wodarz. Published in PLOS Computational Biology December 2021. https://doi.org/10.1371/journal.pcbi.1009713

Evolution of mutants in fragmented populations


  • Evolutionary dynamics of cellular metapopulations: fragmentation, cell migration, and mutants. Jesse Kreger, Natalia L. Komarova, and Dominik Wodarz. In preparation.

  • Mathematical modeling of plankton evolution, mixing, and dynamics in global ocean communities. Multiple authors. In progress.

Cell dynamics

  • Signaling delay impact on tumor-immune cell dynamics. Multiple authors. In progress.
  • Characterization of a new HER2 positive mouse model of metastatic breast cancer. Multiple authors. In progress.
  • Corroborating important immune cell types and genes in a lung metastatic model of HER2 positive breast cancer using single-cell RNA sequencing. Multiple authors. In progress.

undergraduate Research Supervised

Fall 2020: Mathematical Modeling of Cancer Dynamics Instructor for research course for two undergraduate students with a focus on carcinogenesis
Spring 2020: Mathematical Modeling of Infectious Disease Dynamics Instructor for research course for two undergraduate students with a focus on modeling the first wave of COVID-19
Summer 2020: Teaching/Research Assistant for MathBioU Assistant supervisor for summer research project for two undergraduate students and one high school student on the the spread of COVID-19 over networks
Summer 2019: Supervisor for project on the evolutionary dynamics of cellular metapopulations with migration for one undergraduate student

past projects

On mathematical modeling of epidermal wound healing. Honors Thesis at Occidental College. Supervised by Ron Buckmire.
Dynamics of particle-laden thin films: viscous fluid on an incline. University of California, Los Angeles Applied Math REU. Supervised by Andrea Bertozzi, Li Wang, and Jeffrey Wong. Work acknowledged in https://iopscience.iop.org/article/10.1088/1361-6544/aab91d