• in vivo virus dynamics (specifically HIV)
• evolution of mutants in fragmented populations
• cell dynamics, signaling, and fate control using mathematical modeling and single-cell sequencing data (specifically during tumorigenesis and metastasis)

projects and publications

Virus dynamics

• Effect of synaptic cell-to-cell transmission and recombination on the evolution of double mutants in HIV. Jesse Kreger, Natalia L. Komarova, and Dominik Wodarz. Published in Journal of the Royal Society Interface March 2020. https://doi.org/10.1098/rsif.2019.0832

• Quantifying the dynamics of viral recombination during free virus and cell-to-cell transmission in HIV-1 infection. Jesse Kreger, Josephine Garcia, Hongtao Zhang, Natalia L. Komarova, Dominik Wodarz, and David N. Levy. Published in Virus Evolution March 2021. https://doi.org/10.1093/ve/veab026

• A hybrid stochastic-deterministic approach to explore multiple infection and evolution in HIV. Jesse Kreger, Natalia L. Komarova, and Dominik Wodarz. Published in PLOS Computational Biology December 2021. https://doi.org/10.1371/journal.pcbi.1009713

Evolution of mutants in fragmented populations

• The role of migration in mutant evolution in fragmented populations. Jesse Kreger, Donovan Brown, Natalia L. Komarova, Dominik Wodarz, and Justin Pritchard. In revision at Journal of Evolutionary Biology 2021. https://www.biorxiv.org/content/10.1101/2021.06.09.447669v1

• Evolutionary dynamics of cellular metapopulations: fragmentation, cell migration, and mutants. Jesse Kreger, Natalia L. Komarova, and Dominik Wodarz. In preparation.

• Mathematical modeling of plankton evolution, mixing, and dynamics in global ocean communities. Multiple authors. In progress.

Cell dynamics

• Signaling delay impact on tumor-immune cell dynamics. Multiple authors. In progress.
• Characterization of a new HER2 positive mouse model of metastatic breast cancer. Multiple authors. In progress.
• Corroborating important immune cell types and genes in a lung metastatic model of HER2 positive breast cancer using single-cell RNA sequencing. Multiple authors. In progress.

undergraduate Research Supervised

past projects